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/* Bone marrow-derived exosome research page */
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/* NK cell-derived exosome research page */
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/* miRNA testing editorial page */
.mirna-page{--mi-navy:#082f66;--mi-blue:#1476d4;--mi-violet:#6f68df;background:#fff}.mirna-page .site-header{position:relative;z-index:20;max-width:1280px;margin:auto;background:rgba(255,255,255,.96)}.mirna-article>section:not(.bm-data-note){padding-left:max(28px,calc((100vw - 1240px)/2));padding-right:max(28px,calc((100vw - 1240px)/2))}.mirna-wrap{position:relative;width:min(1240px,100%);margin:auto}.mirna-label{color:#345b9b;font:600 13px "Noto Sans JP",sans-serif;letter-spacing:.25em}.mirna-hero{position:relative;min-height:510px;overflow:hidden;background:radial-gradient(circle at 69% 45%,#eff2ff 0,#e9f5fc 33%,#fff 72%)}.mirna-hero .mirna-wrap{display:grid;grid-template-columns:minmax(450px,.88fr) minmax(500px,1.12fr) 185px;min-height:510px}.mirna-hero-copy{position:relative;z-index:3;padding:62px 0 45px}.mirna-hero-copy h1{margin:14px 0 4px;color:var(--mi-navy);font:500 clamp(56px,5vw,72px)/1.08 Georgia,"Yu Mincho",serif}.mirna-hero-copy h2{margin:7px 0 14px;color:#0c427c;font-size:26px;line-height:1.55}.mirna-hero-copy>p:last-of-type{max-width:520px;margin:0;color:#365e7f;font:500 13px/1.9 "Noto Sans JP",sans-serif}.mirna-hero-copy>a{display:flex;align-items:center;justify-content:center;width:285px;height:48px;margin-top:23px;border-radius:99px;background:linear-gradient(135deg,#0c75c7,#074e9c);color:#fff;font:700 12px "Noto Sans JP",sans-serif}.mirna-hero-copy>a b{margin-left:18px;font-size:18px}.mirna-hero-art{position:absolute;z-index:1;width:580px;max-width:none;right:310px;top:46px;filter:drop-shadow(0 20px 40px rgba(70,90,180,.14))}.mirna-hero aside{position:relative;z-index:3;align-self:center;color:var(--mi-navy)}.mirna-hero aside p{font-size:20px;line-height:1.55}.mirna-hero aside i{display:block;width:28px;margin:14px 0;border-top:1px solid #306ca2}.mirna-hero aside span{font:10px/1.6 "Noto Sans JP",sans-serif;letter-spacing:.18em;color:#416b9b}.mirna-now{position:relative;min-height:270px;overflow:hidden;background:#eef8fe}.mirna-now-bg{position:absolute;inset:0;background:url('/assets/optimized/cd20000651d3fc5a-2172.webp') left center/cover no-repeat}.mirna-now .mirna-wrap{display:grid;grid-template-columns:1.25fr 2fr;align-items:center;min-height:270px}.mirna-now-copy{padding-left:210px}.mirna-now-copy h2{margin:0;color:var(--mi-navy);font-size:26px;line-height:1.55}.mirna-now-copy p{max-width:390px;color:#356183;font:11px/1.85 "Noto Sans JP",sans-serif}.mirna-now-points{display:grid;grid-template-columns:repeat(3,1fr);gap:30px;padding-left:35px}.mirna-now-points>div{text-align:center}.mirna-now-points i{display:grid;width:76px;height:76px;margin:0 auto 12px;place-items:center;border-radius:50%;background:rgba(255,255,255,.75);color:#1978d3;font:35px Georgia,serif}.mirna-now-points h3{margin:0 0 8px;color:var(--mi-navy);font-size:19px}.mirna-now-points p{margin:0;color:#3b6483;font:10px/1.7 "Noto Sans JP",sans-serif}.mirna-teaches{min-height:380px;padding-top:55px;padding-bottom:50px;background:linear-gradient(90deg,#fff 0,#fff 35%,#edf8ff 100%)}.mirna-teaches .mirna-wrap{display:grid;grid-template-columns:38% 62%;align-items:center}.mirna-teaches-copy{position:relative;z-index:3}.mirna-teaches-copy h2{margin:0;color:var(--mi-navy);font-size:34px;line-height:1.45}.mirna-teaches-copy p{max-width:440px;color:#315c7e;font:12px/1.9 "Noto Sans JP",sans-serif}.mirna-teaches-copy a{color:#0f72bd;font:700 11px "Noto Sans JP",sans-serif}.mirna-body-map{position:relative;height:330px;overflow:hidden}.mirna-body-map>img{position:absolute;width:172%;height:100%;left:-72%;top:0;object-fit:cover;object-position:center}.mirna-body-map ul{position:absolute;inset:0;margin:0;padding:0;list-style:none}.mirna-body-map li{position:absolute;width:180px;padding:10px 13px 10px 70px;border-radius:99px;background:transparent;color:#174d79}.mirna-body-map li:before{display:none}.mirna-body-map li b,.mirna-body-map li span{display:block;font-family:"Noto Sans JP",sans-serif}.mirna-body-map li b{font-size:11px}.mirna-body-map li span{font-size:8px;line-height:1.5}.mirna-body-map .cancer{left:1%;top:12%}.mirna-body-map .immune{left:0;top:43%}.mirna-body-map .metabolic{left:3%;bottom:5%}.mirna-body-map .neuro{right:0;top:10%}.mirna-body-map .cardio{right:1%;top:42%}.mirna-body-map .aging{right:3%;bottom:6%}.mirna-analysis{position:relative;min-height:385px;padding-top:58px;padding-bottom:55px;overflow:hidden;background:#041a33;color:#fff}.mirna-analysis>img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover}.mirna-analysis:after{content:"";position:absolute;inset:0;background:linear-gradient(90deg,rgba(2,22,44,.92),rgba(3,25,50,.5) 55%,rgba(2,18,37,.86))}.mirna-analysis .mirna-wrap{z-index:2;display:grid;grid-template-columns:1.05fr .7fr .6fr;gap:35px;align-items:center}.mirna-analysis-copy h2{margin:0;font-size:34px;line-height:1.45}.mirna-analysis-copy p{max-width:480px;font:11px/1.9 "Noto Sans JP",sans-serif;color:#dcebf6}.mirna-analysis-copy a{display:flex;align-items:center;justify-content:center;width:245px;height:45px;margin-top:22px;border-radius:99px;background:#fff;color:#144a78;font:700 11px "Noto Sans JP",sans-serif}.mirna-analysis dl{margin:0;padding:4px 25px;border-left:1px solid rgba(255,255,255,.35);border-right:1px solid rgba(255,255,255,.35)}.mirna-analysis dl div{padding:9px 0}.mirna-analysis dt{font:700 10px "Noto Sans JP",sans-serif}.mirna-analysis dd{margin:3px 0 0;color:#d4e4f1;font:9px "Noto Sans JP",sans-serif}.mirna-analysis aside p{font-size:19px;line-height:1.5}.mirna-analysis aside span{font:9px/1.6 "Noto Sans JP",sans-serif;letter-spacing:.16em;color:#bcd6eb}.mirna-future{padding-top:52px;padding-bottom:55px;background:linear-gradient(90deg,#fff 0,#fff 72%,#edf7ff)}.mirna-future header{display:grid;grid-template-columns:1fr 280px;gap:40px;margin-bottom:20px}.mirna-future header h2{margin:0;color:var(--mi-navy);font-size:30px}.mirna-future header>div p{color:#416886;font:11px "Noto Sans JP",sans-serif}.mirna-future header aside{grid-row:1/3;grid-column:2;padding-left:28px;border-left:1px solid #d7e7f2}.mirna-future header aside p{margin:0 0 15px;color:var(--mi-navy);font-size:18px;line-height:1.5}.mirna-future header aside a{display:inline-flex;padding:11px 18px;border:1px solid #338bd0;border-radius:99px;color:#126cb2;font:700 10px "Noto Sans JP",sans-serif}.mirna-future-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:10px;margin-right:300px}.mirna-future-grid article{border:1px solid #d8e8f1;background:#fff}.mirna-future-grid img{width:100%;height:115px;object-fit:cover}.mirna-future-grid h3{margin:11px 13px 5px;color:var(--mi-navy);font-size:13px}.mirna-future-grid p{min-height:32px;margin:0 13px 12px;color:#55748a;font:9px/1.5 "Noto Sans JP",sans-serif}.mirna-featured,.mirna-related{padding-top:55px;padding-bottom:55px}.mirna-featured header p,.mirna-related header p{margin:0;color:#739dbc;font:10px "Noto Sans JP",sans-serif;letter-spacing:.15em}.mirna-featured header h2,.mirna-related header h2{margin:4px 0 20px;color:var(--mi-navy);font-size:30px}.mirna-paper-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:16px}.mirna-paper-grid article{display:grid;grid-template-rows:155px 1fr;border:1px solid #d7e6ef;background:#fff}.mirna-paper-grid img{width:100%;height:100%;object-fit:cover}.mirna-paper-grid article>div{padding:17px}.mirna-paper-grid small{color:#6487a0;font:9px "Noto Sans JP",sans-serif}.mirna-paper-grid h3{margin:8px 0;color:var(--mi-navy);font-size:16px;line-height:1.45}.mirna-paper-grid p{color:#557288;font:10px/1.7 "Noto Sans JP",sans-serif}.mirna-paper-grid a{color:#1476b9;font:700 10px "Noto Sans JP",sans-serif}.mirna-related{background:#f5faff}.mirna-related .mirna-wrap>div{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}.mirna-related a{display:grid;grid-template-columns:75px 1fr 30px;align-items:center;min-height:90px;padding:10px 15px;border:1px solid #d7e7f0;background:#fff;color:var(--mi-navy)}.mirna-related img{width:65px;height:65px;object-fit:contain}.mirna-related span{font-size:15px}.mirna-related b{color:#1980c7;font-size:20px}.mirna-page footer{max-width:1240px;margin:auto}.mirna-method-page{max-width:1050px;margin:0 auto;padding:60px 28px}.mirna-method-page>header nav{display:flex;gap:9px;margin-bottom:35px;color:#64839b;font:10px "Noto Sans JP",sans-serif}.mirna-method-page>header>p{color:#596cd2;font:11px "Noto Sans JP",sans-serif;letter-spacing:.2em}.mirna-method-page h1{margin:12px 0;color:var(--mi-navy);font-size:48px;line-height:1.4}.mirna-method-page>header>p:last-child{max-width:700px;color:#476982;font:13px/1.9 "Noto Sans JP",sans-serif}.mirna-method-list{margin-top:50px;border-top:1px solid #d5e5ef}.mirna-method-list section{display:grid;grid-template-columns:95px 1fr;gap:25px;padding:28px 0;border-bottom:1px solid #d5e5ef}.mirna-method-list section>span{color:#5270d5;font:34px Georgia,serif}.mirna-method-list h2{margin:0 0 8px;color:var(--mi-navy);font-size:22px}.mirna-method-list p{margin:0;color:#4d6e85;font:12px/1.8 "Noto Sans JP",sans-serif}.mirna-method-page>footer{padding:35px 0;text-align:right}.mirna-method-page>footer a{color:#1677bd;font:700 12px "Noto Sans JP",sans-serif}
@media(max-width:1080px){.mirna-hero .mirna-wrap{grid-template-columns:minmax(400px,.85fr) 1.15fr}.mirna-hero aside{display:none}.mirna-hero-art{width:700px;right:-50px}.mirna-now-copy{padding-left:160px}.mirna-teaches .mirna-wrap{grid-template-columns:42% 58%}.mirna-body-map li{width:150px}.mirna-analysis .mirna-wrap{grid-template-columns:1fr .8fr}.mirna-analysis aside{display:none}.mirna-future-grid{margin-right:0}.mirna-future header{grid-template-columns:1fr 250px}}
@media(max-width:700px){.mirna-article>section:not(.bm-data-note){padding-left:18px;padding-right:18px}.mirna-hero{min-height:660px}.mirna-hero .mirna-wrap{display:block}.mirna-hero-copy{padding:38px 0 0}.mirna-label{font-size:9px}.mirna-hero-copy h1{font-size:47px}.mirna-hero-copy h2{font-size:20px}.mirna-hero-copy>p:last-of-type{font-size:11px}.mirna-hero-copy>a{width:240px}.mirna-hero-art{width:650px;right:-235px;top:310px}.mirna-now{min-height:610px}.mirna-now-bg{background-position:25% center;background-size:auto 100%}.mirna-now .mirna-wrap{display:block;padding-top:250px}.mirna-now-copy{padding:0}.mirna-now-copy h2{font-size:23px}.mirna-now-points{gap:8px;padding:0}.mirna-now-points i{width:60px;height:60px;font-size:27px}.mirna-now-points h3{font-size:16px}.mirna-now-points p{font-size:8px}.mirna-teaches{padding-top:38px;padding-bottom:38px}.mirna-teaches .mirna-wrap{display:block}.mirna-teaches-copy h2{font-size:28px}.mirna-body-map{height:430px;margin-top:20px}.mirna-body-map>img{width:215%;left:-112%}.mirna-body-map li{width:132px;padding-left:54px}.mirna-body-map .cancer,.mirna-body-map .immune,.mirna-body-map .metabolic{left:0}.mirna-body-map .neuro,.mirna-body-map .cardio,.mirna-body-map .aging{right:0}.mirna-analysis{min-height:650px;padding-top:40px;padding-bottom:40px}.mirna-analysis .mirna-wrap{display:block}.mirna-analysis-copy h2{font-size:28px}.mirna-analysis dl{margin-top:30px;border-right:0}.mirna-future{padding-top:38px;padding-bottom:40px}.mirna-future header{display:block}.mirna-future header h2{font-size:26px}.mirna-future header aside{margin:22px 0;padding:15px 0 0;border-left:0;border-top:1px solid #d7e7f2}.mirna-future-grid{grid-template-columns:1fr 1fr}.mirna-future-grid img{height:100px}.mirna-featured,.mirna-related{padding-top:38px;padding-bottom:38px}.mirna-paper-grid{grid-template-columns:1fr}.mirna-related .mirna-wrap>div{grid-template-columns:1fr}.mirna-method-page{padding:35px 18px}.mirna-method-page h1{font-size:34px}.mirna-method-list section{grid-template-columns:58px 1fr;gap:12px}.mirna-method-list section>span{font-size:26px}.mirna-method-list h2{font-size:18px}}

/* Faithful hero composition: independent RNA and blood-tube layers */
.mirna-hero:before{content:"";position:absolute;inset:0;background:radial-gradient(circle at 48% 26%,rgba(116,173,225,.28) 0 11px,transparent 25px),radial-gradient(circle at 69% 18%,rgba(142,123,224,.22) 0 8px,transparent 24px),radial-gradient(circle at 77% 70%,rgba(91,168,224,.18) 0 18px,transparent 45px),radial-gradient(circle at 58% 78%,rgba(255,255,255,.85) 0 12px,transparent 35px)}.mirna-hero-art{position:absolute;z-index:1;width:650px;height:440px;right:230px;top:28px;filter:none}.mirna-hero-art img{position:absolute;max-width:none;filter:drop-shadow(0 18px 28px rgba(59,84,169,.14))}.mirna-hero-art .rna{width:385px;left:0;top:58px}.mirna-hero-art .tube{width:390px;right:0;top:0}.mirna-hero aside{grid-column:3;padding-left:20px}.mirna-hero-copy{max-width:455px}.mirna-hero-copy h1{font-size:64px}.mirna-hero-copy h2{font-size:24px}.mirna-hero-copy>p:last-of-type{font-size:12px;line-height:1.8}.mirna-now,.mirna-teaches,.mirna-analysis,.mirna-future{border-top:1px solid rgba(200,225,240,.35)}
@media(max-width:1080px){.mirna-hero-art{width:620px;height:430px;right:-10px;top:35px}.mirna-hero-art .rna{width:360px;left:0;top:55px}.mirna-hero-art .tube{width:370px;right:0}.mirna-hero-copy{max-width:420px}.mirna-hero-copy h1{font-size:58px}}
@media(max-width:700px){.mirna-hero-art{width:470px;height:330px;right:-55px;top:315px}.mirna-hero-art .rna{width:270px;left:0;top:55px}.mirna-hero-art .tube{width:285px;right:0;top:5px}.mirna-hero-copy{max-width:none}.mirna-hero-copy h1{font-size:47px}}

/* Final layout ratios measured from the supplied completed composition */
@media(min-width:1081px){.mirna-hero,.mirna-hero .mirna-wrap{min-height:640px}.mirna-hero-copy{padding-top:105px}.mirna-hero-art{top:74px}.mirna-now,.mirna-now .mirna-wrap{min-height:330px}.mirna-now-copy{padding-left:230px}.mirna-teaches{min-height:410px;padding-top:55px;padding-bottom:55px;background:url('/assets/optimized/d8332f81a203abf8-2175.webp') center/cover no-repeat}.mirna-body-map>img{display:none}.mirna-analysis{min-height:410px}.mirna-future{padding-top:64px;padding-bottom:64px}.mirna-future-grid img{height:135px}.mirna-hero-copy>p:last-of-type{max-width:480px;font-size:14px}.mirna-teaches-copy p,.mirna-analysis-copy p{font-size:13px;max-width:460px}}
@media(max-width:700px){.mirna-hero{min-height:auto;padding-top:0!important;padding-bottom:38px!important}.mirna-hero .mirna-wrap{display:flex;flex-direction:column}.mirna-hero-art{position:relative;order:-1;align-self:center;width:440px;height:295px;right:auto;top:auto;margin:-5px -25px 0}.mirna-hero-art .rna{width:255px;left:6px;top:47px}.mirna-hero-art .tube{width:270px;right:0;top:0}.mirna-hero-copy{padding-top:12px}.mirna-teaches{background:none;min-height:auto}.mirna-teaches .mirna-wrap{display:flex;flex-direction:column}.mirna-body-map{order:-1;width:100%;height:420px;margin:0 0 28px;background:#edf8ff}.mirna-body-map>img{display:block}.mirna-analysis{min-height:auto;padding-top:270px}.mirna-analysis>img{height:235px;object-fit:cover}.mirna-analysis:after{height:235px;bottom:auto}.mirna-analysis .mirna-wrap{position:relative}.mirna-analysis dl{padding-bottom:0}.mirna-now{min-height:auto;padding-bottom:35px!important}.mirna-now .mirna-wrap{padding-top:265px}}

/* miRNA middle sections: exact composition from the approved reference. */
.mirna-woman{overflow:hidden}.mirna-woman img{display:block;width:100%;height:100%;object-fit:cover;object-position:left center}.mirna-now-points i img{display:block;width:100%;height:100%;object-fit:contain}.mirna-body-map .body-figure{display:block}.mirna-body-map li img{display:block;object-fit:contain}.mirna-body-map li small{display:block;font-family:"Noto Sans JP",sans-serif;font-weight:500}
@media(min-width:1081px){
 .mirna-now{height:275px;min-height:275px;padding:0!important;overflow:hidden;background:#eef8fe}
 .mirna-now-bg{display:none}
 .mirna-now .mirna-wrap{display:grid;width:min(1440px,100%);height:275px;min-height:275px;grid-template-columns:20% 27% 17% 17% 19%;align-items:center}
 .mirna-woman{width:100%;height:275px}
 .mirna-now-copy{min-width:260px;padding:0 28px 0 42px;box-sizing:border-box}
 .mirna-now-copy h2{margin:0 0 10px;color:var(--mi-navy);font-size:28px;line-height:1.5;letter-spacing:.02em}
 .mirna-now-copy p{max-width:270px;margin:0;color:#356183;font:500 14px/1.8 "Noto Sans JP",sans-serif}
 .mirna-now-points{display:contents}
 .mirna-now-points>div{align-self:center;padding:0 10px;text-align:center}
 .mirna-now-points i{display:grid;width:84px;height:84px;margin:0 auto 10px;padding:0;place-items:center;border-radius:50%;background:rgba(255,255,255,.72)}
 .mirna-now-points h3{margin:0 0 5px;color:var(--mi-navy);font:500 21px/1.4 Georgia,"Yu Mincho",serif}
 .mirna-now-points p{max-width:150px;margin:0 auto;color:#3b6483;font:500 13px/1.7 "Noto Sans JP",sans-serif}
 .mirna-teaches{height:390px;min-height:390px;padding:0!important;overflow:hidden;background:#f7fbfe}
 .mirna-teaches .mirna-wrap{display:grid;width:min(1280px,100%);height:390px;grid-template-columns:38% 62%;align-items:stretch}
 .mirna-teaches-copy{padding:48px 40px 36px 52px;box-sizing:border-box}
 .mirna-teaches-copy h2{max-width:330px;margin:0 0 13px;font-size:34px;line-height:1.45}
 .mirna-teaches-copy p{max-width:360px;margin:0 0 12px;color:#315c7e;font:500 15px/1.85 "Noto Sans JP",sans-serif}
 .mirna-teaches-copy a{font:700 13px "Noto Sans JP",sans-serif}
 .mirna-body-map{position:relative;width:100%;height:390px;margin:0;overflow:hidden;background:linear-gradient(90deg,#f7fbfe,#e7f5ff)}
 .mirna-body-map .body-figure{position:absolute;z-index:1;width:auto;height:330px;left:50%;top:50%;transform:translate(-50%,-50%);object-fit:contain}
 .mirna-body-map ul{position:absolute;z-index:2;inset:0;margin:0;padding:0;list-style:none}
 .mirna-body-map li{position:absolute;display:grid;width:210px;height:78px;padding:0 14px;box-sizing:border-box;grid-template-columns:48px 1fr;gap:10px;align-items:center;border-radius:40px;background:rgba(255,255,255,.72);color:#174d79}
 .mirna-body-map li img{width:48px;height:48px}
 .mirna-body-map li>span{display:block}
 .mirna-body-map li b{display:block;font:600 15px/1.35 "Noto Sans JP",sans-serif}
 .mirna-body-map li small{margin-top:2px;color:#466b88;font-size:11px;line-height:1.5}
 .mirna-body-map .cancer{left:0;top:20px}.mirna-body-map .immune{left:0;top:156px}.mirna-body-map .metabolic{left:0;bottom:20px}
 .mirna-body-map .neuro{right:0;top:20px}.mirna-body-map .cardio{right:0;top:156px}.mirna-body-map .aging{right:0;bottom:20px}
}
@media(min-width:701px) and (max-width:1080px){
 .mirna-now{height:275px;min-height:275px;padding:0!important}.mirna-now-bg{display:none}.mirna-now .mirna-wrap{display:grid;width:100%;height:275px;grid-template-columns:20% 27% 17% 17% 19%;align-items:center}.mirna-woman{height:275px}.mirna-now-copy{min-width:0;padding:0 18px}.mirna-now-copy h2{font-size:22px;line-height:1.45}.mirna-now-copy p{font-size:11px;line-height:1.7}.mirna-now-points{display:contents}.mirna-now-points>div{padding:0 5px;text-align:center}.mirna-now-points i{width:68px;height:68px}.mirna-now-points h3{font-size:18px}.mirna-now-points p{font-size:10px;line-height:1.55}
 .mirna-teaches{height:390px;min-height:390px;padding:0!important;background:#f7fbfe}.mirna-teaches .mirna-wrap{display:grid;height:390px;grid-template-columns:38% 62%;align-items:stretch}.mirna-teaches-copy{padding:42px 24px 30px}.mirna-teaches-copy h2{font-size:27px}.mirna-teaches-copy p{font-size:12px;line-height:1.75}.mirna-body-map{height:390px;margin:0;background:linear-gradient(90deg,#f7fbfe,#e7f5ff)}.mirna-body-map .body-figure{position:absolute;width:auto;height:285px;left:50%;top:50%;transform:translate(-50%,-50%)}.mirna-body-map li{width:158px;height:66px;padding:0 10px;grid-template-columns:39px 1fr;gap:6px;background:rgba(255,255,255,.78)}.mirna-body-map li img{width:39px;height:39px}.mirna-body-map li b{font-size:12px}.mirna-body-map li small{font-size:8px}.mirna-body-map .cancer{left:0;top:25px}.mirna-body-map .immune{left:0;top:162px}.mirna-body-map .metabolic{left:0;bottom:25px}.mirna-body-map .neuro{right:0;top:25px}.mirna-body-map .cardio{right:0;top:162px}.mirna-body-map .aging{right:0;bottom:25px}
}
@media(max-width:700px){
 .mirna-now{height:auto;min-height:0;padding:0 18px 34px!important;background:#eef8fe}.mirna-now-bg{display:none}.mirna-now .mirna-wrap{display:flex;height:auto;padding:0;flex-direction:column}.mirna-woman{width:calc(100% + 36px);height:225px;margin:0 -18px 26px}.mirna-now-copy{min-width:0;padding:0}.mirna-now-copy h2{margin:0 0 10px;font-size:25px;line-height:1.5}.mirna-now-copy p{max-width:none;margin:0;font-size:12px;line-height:1.8}.mirna-now-points{display:grid;width:100%;margin-top:25px;padding:0;grid-template-columns:repeat(3,1fr);gap:8px}.mirna-now-points>div{text-align:center}.mirna-now-points i{width:66px;height:66px;margin-bottom:9px;padding:0}.mirna-now-points h3{font-size:18px}.mirna-now-points p{font-size:9px;line-height:1.55}
 .mirna-teaches{height:auto;min-height:0;padding:0 18px 38px!important;background:#f7fbfe}.mirna-teaches .mirna-wrap{display:flex;height:auto;flex-direction:column}.mirna-body-map{order:-1;width:calc(100% + 36px);height:415px;margin:0 -18px 28px;background:linear-gradient(90deg,#f7fbfe,#e7f5ff)}.mirna-body-map .body-figure{position:absolute;width:auto;height:235px;left:50%;top:50%;transform:translate(-50%,-50%)}.mirna-body-map li{display:grid;width:126px;height:58px;padding:0 7px;grid-template-columns:32px 1fr;gap:4px;align-items:center;border-radius:30px;background:rgba(255,255,255,.8)}.mirna-body-map li img{width:32px;height:32px}.mirna-body-map li b{font-size:10px;line-height:1.25}.mirna-body-map li small{font-size:7px;line-height:1.35}.mirna-body-map .cancer{left:4px;top:24px}.mirna-body-map .immune{left:4px;top:178px}.mirna-body-map .metabolic{left:4px;bottom:24px}.mirna-body-map .neuro{right:4px;top:24px}.mirna-body-map .cardio{right:4px;top:178px}.mirna-body-map .aging{right:4px;bottom:24px}.mirna-teaches-copy{padding:0}.mirna-teaches-copy h2{max-width:330px;font-size:28px;line-height:1.45}.mirna-teaches-copy p{max-width:none;font-size:12px;line-height:1.85}.mirna-teaches-copy a{font-size:11px}
}

/* miRNA hero: reference-image proportions and visual hierarchy. */
@media(min-width:1081px){
 .mirna-page .site-header{height:72px;max-width:1280px;padding:0 28px}
 .mirna-page .site-brand .caseloop-logo{width:150px!important;height:58px!important}
 .mirna-hero,.mirna-hero .mirna-wrap{height:480px;min-height:480px}
 .mirna-hero{padding-left:max(48px,calc((100vw - 1344px)/2))!important;padding-right:max(48px,calc((100vw - 1344px)/2))!important;background:radial-gradient(circle at 70% 46%,rgba(255,255,255,.96) 0 8%,rgba(224,242,254,.82) 35%,rgba(255,255,255,.98) 73%)}
 .mirna-hero .mirna-wrap{width:min(1344px,100%);grid-template-columns:42% 42% 16%}
 .mirna-hero-copy{max-width:500px;padding:42px 0 30px}
 .mirna-label{font-size:15px}
 .mirna-hero-copy h1{margin:12px 0 2px;font-size:64px;line-height:1.08}
 .mirna-hero-copy h2{margin:6px 0 12px;font-size:27px;line-height:1.48}
 .mirna-hero-copy>p:last-of-type{max-width:475px;font-size:14px;line-height:1.85}
 .mirna-hero-copy>a{width:285px;height:50px;margin-top:18px}
 .mirna-hero-art{width:555px;height:420px;right:215px;top:6px}
 .mirna-hero-art .rna{width:340px;left:3px;top:78px}
 .mirna-hero-art .tube{width:340px;right:0;top:0}
 .mirna-hero aside{padding-left:18px}
 .mirna-hero aside p{font-size:20px}
}
@media(min-width:701px) and (max-width:1080px){
 .mirna-page .site-header{height:64px;padding:0 32px}
 .mirna-page .site-brand .caseloop-logo{width:145px!important;height:54px!important}
 .mirna-page .site-header nav{gap:17px;font-size:10px}
 .mirna-page .site-header nav a:nth-child(4),.mirna-page .site-header nav a:nth-child(5),.mirna-page .site-header nav a:nth-child(6){display:none}
 .mirna-hero,.mirna-hero .mirna-wrap{height:465px;min-height:465px}
 .mirna-hero{padding-left:28px!important;padding-right:28px!important}
 .mirna-hero .mirna-wrap{width:100%;grid-template-columns:43% 57%}
 .mirna-hero-copy{max-width:440px;padding:38px 0 24px}
 .mirna-label{font-size:12px}
 .mirna-hero-copy h1{margin:10px 0 2px;font-size:55px}
 .mirna-hero-copy h2{font-size:23px;line-height:1.48}
 .mirna-hero-copy>p:last-of-type{max-width:390px;font-size:12px;line-height:1.8}
 .mirna-hero-copy>a{width:255px;height:47px;margin-top:18px}
 .mirna-hero-art{width:540px;height:410px;right:-20px;top:8px}
 .mirna-hero-art .rna{width:330px;left:0;top:78px}
 .mirna-hero-art .tube{width:330px;right:0;top:2px}
}

/* Explicit component placement: keeps artwork and copy aligned at every width. */
.domain-grid article{grid-template-columns:58px minmax(0,1fr);grid-template-rows:auto minmax(112px,1fr) auto auto;align-content:start}.domain-number{grid-column:1;grid-row:1;align-self:start}.domain-title{grid-column:2;grid-row:1;min-width:0;padding-top:1px}.domain-title h4{overflow-wrap:anywhere}.domain-body{grid-column:1/-1;grid-row:2;display:grid;grid-template-columns:82px minmax(0,1fr);align-items:center;gap:16px;min-height:112px;padding:12px 0}.domain-body img{display:block;width:82px;height:82px;object-fit:contain}.domain-body p{margin:0;color:#536f82;font:11px/1.75 "Noto Sans JP","Yu Gothic",sans-serif;overflow-wrap:anywhere}.domain-grid dl{grid-row:3}.domain-grid article>a{grid-row:4}.domain-grid article>img,.domain-grid article>p{display:none}
.doctor-update>div:last-child{display:grid;grid-template-columns:minmax(0,1fr) minmax(190px,44%);grid-template-rows:auto auto auto auto;column-gap:12px;min-height:238px;padding:24px 0 22px 25px}.doctor-update>div>span,.doctor-update>div>h3,.doctor-update>div>p,.doctor-update>div>a{grid-column:1;position:relative;z-index:2}.doctor-update>div>img{grid-column:2;grid-row:1/-1;position:static;align-self:end;width:100%;height:100%;max-height:238px;object-fit:contain;object-position:right bottom}.doctor-update h3{margin:8px 0}.doctor-update p{margin:0}.doctor-update a{justify-self:start}
@media(max-width:700px){.domain-grid article{display:grid;grid-template-columns:52px minmax(0,1fr);grid-template-rows:auto minmax(96px,auto) auto auto}.domain-body{grid-template-columns:68px minmax(0,1fr);gap:12px;min-height:96px;padding:9px 0}.domain-body img{width:68px;height:68px}.domain-body p{font-size:10px}.doctor-update>div:last-child{grid-template-columns:minmax(0,1fr) minmax(130px,42%);min-height:230px;padding:20px 0 18px 18px}.doctor-update>div>img{max-height:230px}}





/* Supplied September 20 hero artwork; text remains accessible HTML. */
.mirna-hero-background{position:absolute;inset:0;display:block;width:100%;height:100%;object-fit:cover;object-position:center}
.mirna-hero:before{display:none}
.mirna-scroll{display:block;width:26%;margin:14px 0 0;text-align:center;color:#0654a9;font:8px/1.4 Arial,sans-serif;letter-spacing:.12em}
.mirna-scroll:after{content:"";display:block;height:22px;width:1px;background:#1268ba;margin:7px auto 0}
@media(min-width:701px){
 .mirna-page .site-header{height:4.6875vw;min-height:48px;max-width:none;padding:0 5%;background:#f6fbff}
 .mirna-page .site-brand .caseloop-logo{width:110px!important;height:55px!important}
 .mirna-hero{height:38.4765625vw;min-height:0;padding:0!important;background:#eff8fe}
 .mirna-hero .mirna-wrap{display:block;width:100%;height:100%;min-height:0;margin:0}
 .mirna-hero-copy{position:absolute;left:5%;top:10%;padding:0;width:38%;max-width:none}
 .mirna-hero-copy .mirna-label{margin:0 0 1vw;font:400 1.65vw/1.4 Arial,sans-serif;letter-spacing:.18em;color:#072c76}
 .mirna-hero-copy h1{margin:0 0 .6vw;font-size:5.85vw;line-height:1.08;color:#062b71;font-weight:500;letter-spacing:0}
 .mirna-hero-copy h2{margin:0 0 1vw;font-size:2.35vw;line-height:1.4;color:#092f76;font-weight:500}
 .mirna-hero-copy>p:last-of-type{margin:0;width:100%;max-width:none;color:#164176;font:400 1.15vw/1.8 "Yu Gothic",sans-serif;letter-spacing:0}
 .mirna-hero-copy>a{width:26vw;height:4.1vw;margin-top:1.5vw;font:500 1.15vw "Yu Gothic",sans-serif;background:linear-gradient(#087bdf,#064caf)}
 .mirna-hero-copy>a b{font-size:1.6vw;font-weight:400}
 .mirna-scroll{width:26vw;font-size:.78vw;margin-top:1.3vw}
 .mirna-scroll:after{height:2.15vw;margin-top:.65vw}
 .mirna-hero aside{display:block;position:absolute;left:82.6%;top:50%;width:17%;padding:0;color:#092f76}
 .mirna-hero aside p{margin:0;font-size:1.75vw;line-height:1.5;white-space:nowrap}
 .mirna-hero aside i{width:2.6vw;margin:1.1vw 0 1.4vw;border-color:#6b96c9}
 .mirna-hero aside span{display:block;font:400 .94vw/1.45 Arial,sans-serif;letter-spacing:.15em;color:#123e7d}
}
@media(max-width:700px){
 .mirna-hero{height:auto;min-height:0;padding:0 18px 30px!important;background:#f4faff}
 .mirna-hero-background{position:relative;width:calc(100% + 36px);height:240px;margin:0 -18px;object-fit:cover;object-position:right center}
 .mirna-hero .mirna-wrap{display:block;height:auto;min-height:0}
 .mirna-hero-copy{position:relative;padding:24px 0 0;width:100%;max-width:none}
 .mirna-hero-copy>p:last-of-type{font-weight:400;font-size:12px}
 .mirna-hero-copy>p:last-of-type br{display:none}
 .mirna-hero aside,.mirna-scroll{display:none}
}
@media(min-width:701px){.mirna-page .site-brand .caseloop-logo{width:96px!important;height:48px!important}}
/* Supplied woman-and-icons composition, with HTML text aligned to its landmarks. */
@media(min-width:701px){
 .mirna-now{height:21.484375vw;min-height:0;padding:0!important;background:#f2f9fe url('/assets/optimized/cd20000651d3fc5a-2172.webp') center/100% 100% no-repeat;border:0}
 .mirna-now .mirna-wrap{display:block;position:relative;width:100%;max-width:none;height:100%;min-height:0;padding:0}
 .mirna-now .mirna-woman{display:none}
 .mirna-now-copy{position:absolute;left:21.7%;top:19.5%;width:27%;min-width:0;padding:0}
 .mirna-now-copy h2{margin:0 0 1.15vw;font-size:2.2vw;line-height:1.4;letter-spacing:0;font-weight:500;white-space:nowrap}
 .mirna-now-copy p{max-width:none;margin:0;font:400 1.12vw/1.65 "Yu Gothic",sans-serif;color:#194779}
 .mirna-now-points{display:contents}
 .mirna-now-points>div{position:absolute;top:51%;width:15.6%;padding:0;text-align:center}
 .mirna-now-points>div:nth-child(1){left:49%}
 .mirna-now-points>div:nth-child(2){left:65.45%}
 .mirna-now-points>div:nth-child(3){left:81.8%}
 .mirna-now-points i{display:none}
 .mirna-now-points h3{margin:0 0 .35vw;font:500 1.9vw/1.4 "Yu Mincho",serif;color:#092f76}
 .mirna-now-points p{max-width:none;margin:0;font:400 1.1vw/1.65 "Yu Gothic",sans-serif;color:#22497c}
}
@media(max-width:700px){
 .mirna-now{background:#eef8fe}
 .mirna-now-copy h2{font-size:23px}
 .mirna-woman img{object-fit:contain;object-position:left center}
}
/* Supplied body-map artwork: retain its anatomy, icons and pill positions. */
@media(min-width:701px){
 .mirna-teaches{position:relative;height:27.44140625vw;min-height:0;padding:0!important;overflow:hidden;border:0;background:#f7fbfe url('/assets/optimized/d8332f81a203abf8-2175.webp') center/100% auto no-repeat}
 .mirna-teaches .mirna-wrap{position:relative;display:block;width:100%;max-width:none;height:100%;margin:0}
 .mirna-teaches-copy{position:absolute;left:5%;top:14%;width:31%;padding:0}
 .mirna-teaches-copy h2{max-width:none;margin:0 0 1.55vw;font-size:3.05vw;line-height:1.23;letter-spacing:0;font-weight:500;white-space:nowrap;color:#082f76}
 .mirna-teaches-copy p{max-width:none;margin:0 0 1.6vw;color:#234b80;font:400 1.17vw/1.72 "Yu Gothic",sans-serif}
 .mirna-teaches-copy a{font:500 1.17vw "Yu Gothic",sans-serif;color:#0878cc}
 .mirna-body-map{position:absolute;inset:0;width:100%;height:100%;margin:0;overflow:visible;background:none;pointer-events:none}
 .mirna-body-map .body-figure,.mirna-body-map li img{display:none}
 .mirna-body-map ul{position:absolute;inset:0;margin:0;padding:0;list-style:none}
 .mirna-body-map li{position:absolute;display:flex;align-items:center;width:12%;height:23%;margin:0;padding:0;border:0;border-radius:0;background:none;color:#12396e;transform:translateY(-50%)}
 .mirna-body-map li>span{display:block}
 .mirna-body-map li b{display:block;font:600 1.22vw/1.4 "Yu Mincho",serif;white-space:nowrap}
 .mirna-body-map li small{display:block;margin-top:.2vw;color:#285181;font:400 .98vw/1.55 "Yu Gothic",sans-serif}
 .mirna-body-map .cancer{left:46.6%;top:19.1%;bottom:auto;right:auto}
 .mirna-body-map .immune{left:44%;top:49.8%;bottom:auto;right:auto}
 .mirna-body-map .metabolic{left:45.7%;top:80.6%;bottom:auto;right:auto}
 .mirna-body-map .neuro{left:84.5%;top:19.1%;bottom:auto;right:auto}
 .mirna-body-map .cardio{left:85.5%;top:49.8%;bottom:auto;right:auto}
 .mirna-body-map .aging{left:85%;top:80.6%;bottom:auto;right:auto}
}
@media(min-width:701px){.mirna-teaches-copy h2{font-size:2.75vw;line-height:1.3}}
@media(min-width:701px){.mirna-analysis .mirna-wrap{grid-template-columns:1.55fr .8fr .6fr;gap:28px}.mirna-analysis dl{padding-left:25px;padding-right:18px}}
@media(min-width:701px){.mirna-analysis .mirna-wrap{grid-template-columns:2.2fr .85fr .6fr;gap:24px}}
@media(min-width:701px){.mirna-analysis .mirna-wrap{grid-template-columns:2.9fr .85fr .6fr;gap:24px}}
@media(min-width:701px){.mirna-analysis .mirna-wrap{grid-template-columns:3.8fr .85fr .6fr;gap:24px}}
@media(min-width:701px){.mirna-analysis-copy p{max-width:none}}
.mirna-analysis dl div:first-child dd{white-space:nowrap}
.mirna-analysis dl div:nth-child(3) dd{white-space:nowrap}

.research-public .research-entrance-return{display:flex;justify-content:center;padding:32px 20px 48px}.research-public .research-entrance-return a{display:inline-flex;align-items:center;justify-content:center;gap:12px;max-width:100%;padding:16px 24px;border:1px solid #bdd8ec;border-radius:8px;background:#f3faff;color:#164d76;font-size:16px;font-weight:700;text-align:center;text-decoration:none}.research-public .research-entrance-return a:hover{background:#e7f5ff}.research-public .research-entrance-return a:focus-visible{outline:3px solid #298ac6;outline-offset:4px}@media(max-width:600px){.research-public .research-entrance-return a{font-size:14px;padding:14px 18px}}

.research-public .research-supervision{width:min(1120px,calc(100% - 40px));margin:40px auto 0}.research-public .research-supervision h2{font-size:24px;margin:0 0 18px}.research-public .research-supervision .research-related-title{margin-top:30px}.research-public .research-organization-card{padding:28px;border:1px solid #dce8ef;border-radius:14px;background:#fff}.research-public .research-organization-card img{display:block;width:min(315px,100%);height:auto}.research-public .research-organization-card p{font-size:16px;line-height:1.85;margin:20px 0 14px}.research-public .research-organization-link{font-size:15px;color:#164d76;text-underline-offset:4px}.research-public .research-organization-link:focus-visible{outline:3px solid #298ac6;outline-offset:4px}@media(max-width:600px){.research-public .research-organization-card{padding:22px 18px}.research-public .research-supervision h2{font-size:21px}.research-public .research-organization-card p{font-size:14px}.research-public .research-organization-link{font-size:14px}}